Embedded Files
Our lab currently focuses on two primary areas: protein engineering and biomaterials. Examples of projects in each area are shown below. Contact us for more information on specific projects.
Protein Engineering
Protein Engineering
This area of the lab involves making new proteins that target specific cell types or tissues. For example, we engineered an anti-inflammatory cytokine drug (IL-10) by making it bind to low-density lipoprotein (LDL or "bad cholesterol") in the blood. Upon injection, the engineering IL-10 binds LDL and hitchhikes a ride to atherosclerotic plaques to reduce vascular inflammation. Read about our work here.
Surface-functionalized polymersomes produce a robust cellular and antibody response in mice.
Biomaterials
Biomaterials
This area of the lab uses natural or synthetic polymers to create targeted nanoparticles with immunomodulatory effects. As an example, we created a vaccine with the antigen chemically conjugated to the surface of polymer vesicles. We are currently exploring different techniques to decorate the surface of the particles with targeting moieties. Read more about our vaccine project here.
Page updated
Google Sites
Report abuse